In space, water becomes a spherical ball, hovering in the air. Plants grow sideways. Humans lose muscle mass. Without earth’s gravity things behave…well, differently. Such is life—and science—aboard the International Space Station, where the extremes of microgravity make possible a whole new class of cutting-edge experiments ranging from fluid dynamics (try drinking a cup of coffee that won’t stay in the cup) to vaccines, and research about the origin of the life to predicting natural disasters. ISS scientists join middle school students from across the country in a virtual classroom that brings research at 240 miles above earth’s surface right down to earth.