Jean-Pierre Issa

Molecular Biologist

Jean-Pierre Issa is a professor of medicine and director at Fels Institute for Cancer Research and Molecular Biology at Temple University. Issa’s laboratory has made important contributions to the understanding of the importance of epigenetics in the pathophysiology and treatment of cancer. His lab’s discoveries include the effects of aging and inflammation on promoter DNA methylation, the CpG Island Methylator Phenotype in multiple cancers, and the interrelations between aberrant DNA methylation and histone modifications in cancer. Starting in 2000, his group initiated laboratory research inspired clinical trials that showed that low doses of hypomethylating drugs specifically target DNA methylation and are optimal in the treatment of leukemias. This work contributed to the FDA approval of decitabine, and led to a large number of epigenetic therapy clinical trials in different malignancies.

Issa’s research focuses on mechanisms of epigenetic alterations in aging and cancer, translation of epigenomic studies for Precision Medicine, development of drugs for reprogramming the epigenome, and clinical trials of epigenetic therapy in cancer. His research has been recognized by numerous awards including a Sidney Kimmell Foundation Scholar Award, election to the American Society of Clinical Investigation, an American Cancer Society clinical research professorship, the Faculty Achievement Award in Basic Research from MD Anderson and the Rosenthal Award.

Participants

Shreya AminStudent

Shreya Amin, a senior at Manhattan Center for Science and Mathematics, has a knack for discovering and learning more about the world through science.

Yemi AmuFarmer, Educator, Owner of Oko Farms

Yemi Amu is the owner and operator of Oko Farms, LLC, an urban aquaponics farm, education, and design company in Brooklyn, New York. Amu is the Farm Manager at the Moore Street Farm, an outdoor aquaponics farm developed by Oko Farms.

Kurt AndersenAuthor, Editor, Radio Host

Kurt Andersen is the author of two novels, the critically acclaimed bestsellers Heyday and Turn of the Century. His forthcoming book is called Reset: How This Crisis Can Restore Our Values and Renew America. He is also host and co-creator of the Peabody Award-winning public radio program Studio 360.

Robert AndersonMountaineer

Robert Anderson has a message that resonates with audiences as he talks of building the smallest team to ascend Everest’s largest face, without oxygen.

Lara AndersonPhysicist

Lara Anderson is an Assistant Professor of Physics and Affiliate Professor of Mathematics, and currently a Hamlett Fellow in Integrated Science at Virginia Tech. She is currently visiting faculty at the Simons Center for Geometry and Physics.

Nancy AndersonSinger

Nancy Anderson has starred on Broadway in A Class Act, Wonderful Town, and the revival of Sunset Boulevard. She is a three-time Drama Desk Nominee and a three-time Helen Hayes Nominee.

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Jean-Pierre Issa

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